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KMID : 0853020110140010001
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Journal of Korean Burn Society
2011 Volume.14 No. 1 p.1 ~ p.5
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Effect of Platelet-rich Plasma on Burn Wounds according to Time of Application: An Experimental Study on Rats
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Lee San-Ha
Choi Tae-Hyun
Kim Suk-Wha
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Abstract
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Purpose: One of the main subjects that burn researches are focused on is saving the zone of stasis. Platelet-rich plasma stimulates angiogenesis, promoting vascular in-growth and fibroblast proliferation. In addition, platelet-rich plasma functions as haemostatic agent by forming a fibrin clot. Also application of platelet-rich plasma enhances wound-healing in both soft and hard tissue. In this study, the effect of the platelet-rich plasma on the zone of stasis was evaluated.
Methods: Sixteen F344/N Slc Inbred Rats were used and randomly separated into four groups. Autologous platelet-rich plasma was harvested and applied to each group of burn wound model at different times.
Results: After 20 days, burn wounds of each group healed well. However, healing speed was different in each group. The group to which platelet-rich plasma was applied 4 hours after burn injury had healed about 1.38 times faster than control group.
Conclusion: The results showed that platelet-rich plasma is an effective substance for saving the zone of stasis. It is not only well-known, but also easy to harvest and easy to use. Thus autologous platelet-rich plasma could be a valuable addition to existing burn treatment methods.
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KEYWORD
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Platelet-rich plasma, Burns, Wound healing
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